Title :

Design and Development of Magnetic Lab-on-a-chip Systems and Massively Parallel Biomolecular Tweezers

Speaker :

Dr. Zhengchun Peng

Senior Research Engineer

Technology Manufacturing Group,Intel Corporation,USA

Venue :

Room 215, William M. W. Mong Engineering Building, CUHK

Date :

Apr 16, 2013, Tuesday
2:00 PM - 3:15 PM

Abstract :

Physically manipulating cells and biomolecules or their environment- using electric fields, magnetic fields, optical forces, atomic force microscopy, and microfluidics- provides new ways to organize cells and interrogate biomolecular interactions. The power and success of these techniques are illustrated by the rapidly growing number of applications and systems to which they are being applied over the past two decades. However, increasing versatility and parallelism are not readily available from the state-of-art tools. In this talk, I will discuss the development of several versatile and high throughput tools for biomolecular studies, all based on parallel manipulation of individual microparticles on a microchip. The particles in our study were monodispersed functionalized polymeric microbeads, inside which paramagnetic nanoparticles are incorporated. Hence, dielectrophoresis (DEP) and magnetophoresis (MAP) can both be used to manipulate these microbeads in fluid. With innovative design of MAP and DEP systems, we realized well controlled in-plane and out-of-plane controls of individual microbeads in parallel. I will demonstrate the application of these particle manipulation methods as the building blocks for a lab-on-a-chip system consists of integrated functions including efficient sample mixing, effective sample concentration and separation with high spatial resolution, as well as in-situ sensitive detection. Furthermore, our approach to combining MAP and DEP of the same microbeads has led to an invention of micro/nano tweezers, suitable for cell mechanics and molecular kinetics studies. The MAP-DEP tweezers allows for high resolution and large dynamic range in tweezing force, and can generate uniform force on microbeads across a macroscopic sampling area, providing a highly parallel platform for cellular/molecular force spectroscopy. Together, these integrated, high precision and massively parallel tools developed in my research provide and expedite ways of exploiting cellular and molecular interactions for both basic science and applied biotechnology.

Biography :

Dr. Zhengchun Peng received his B.S. in Automotive Engineering from Beijing Institute of Technology in 1998, and his M.S. degree in Mechanical Engineering from Louisiana State University in 2002. From 2002 to 2005, he worked as a Research Associate at Center for Advanced Microstructures and Devices (a U.S. synchrotron radiation facility). He then attended Georgia Institute of Technology for his Ph.D. in microelectromechanical systems (MEMS). Upon completion of his Ph.D. in 2010, he worked as a Postdoc and Research Scientist in Georgia Tech/Emory University Joint Department of Biomedical Engineering, developing massively parallel biomolecular tweezers. He then joined Intel Corp. in 2011 as a Senior Research Engineer, working on next generation wafer probing and die packaging technologies. Dr. Peng~s research interests include high resolution and high throughput bioinstrument, lab-on-a-chip, micro/nanofabrication, microelectronics packaging, nano-energy devices and implantable systems. He has published 16 journal articles and been awarded 3 patents in these areas.

    **************************************** ALL ARE WELCOME ****************************************

Enquiries: Ms. Winnie Wong / Flora Au-Yeung, Department of Mechanical and Automation Engineering, CUHK at 3943 8337 / 3943 7026. *MAE Series (2012-13) is contained in the World-Wide Web home page at http://www3.mae.cuhk.edu.hk/mae_seminars.php.

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