Title :

Microfluidic Devices for Cell-based Studies with Clinical Applications

Speaker :

Prof. Andrew M. Wo

Professor, Institute of Applied Mechanics, National Taiwan University, Dean, Research and Development, National University of Kaohsiung

Director, International Affairs, Institute of Engineering Education Taiwan, Taiwan

Venue :

Room 215, William M. W. Mong Engineering Building, CUHK

Date :

Apr 27, 2010, Tuesday
10:00 AM - 11:00 AM

Abstract :

Microfluidics has become an enabling technology to realize lab-on-a-chip systems for biomedical studies towards clinical applications. This talk will present a range of cell-based microfluidic devices developed in the Microfluidics Lab of the Institute of Applied Mechanics, National Taiwan University. Microdevices to be covered include planar patch-clamp for ion channel electrophysiology study, cellular microarray platform for chemotherapeutic studies, rare cell separation and detection, and single cell platform for suspended cell. The planar patch-clamp assay leverages upon a unique hourglass-aperture fabricated on plane glass to perform ion channel measurement with intra- and extra-cellular solution exchange. The cellular microarray platform focuses on drug screen prior to chemotherapeutic treatment of breast cancer patients. Finally, the single cell platform utilizes Lorentz force to generate microvortices and allows characterization of trapping forces on bioparticles. Work in progress of a major funding via the Nano National Project, National Science Council, on integrated combinatorial drug screening and enumeration of circulating tumor cells will also be discussed.

Biography :

Dr. Andrew M. Wo received his MS and PhD (1990) in Fluid Mechanics from MIT. He is a Professor in the Institute of Applied Mechanics at the National Taiwan University, and also serves as Dean of Research and Development at the National University of Kaohsiung. He is also the Director of the International Affairs of the Institute of Engineering Education Taiwan (IEET), a Washington Accord Signatory. Recently, he also has the privilege to serve as the chair of the Washington Accord review panel to Russian Association for Engineering Education, an accreditation body of all engineering programs in Russia.

His main research focus is on the application of microfluidic devices in biology and medicine. The overarching theme for various microfabricated devices is in-vitro lab-on-a-chip platform for cellular assays, which includes single cell assay, cellular microarray for chemotherapeutic study, platform for rare cell analysis, and semen fluid diagnosis, and planar patch clamp assay. He works very closely with many doctors in the National Taiwan University Hospital. His work is published in Lab Chip, Analytical Chemistry, Biosensors and Bioelectronics, and Applied Physics Letters. His awards include Innovative Award, Institute for Biotechnology and Medical Industry; four-times recipient of the Research Excellence Award, National Science Council; three-time recipient of the Teaching Excellence Award, National Taiwan University; and Excellence Engineering Paper Award, Chinese Institute of Engineers. He is also active in his church serving as an elder and a counselor in the college fellowship group.

    **************************************** ALL ARE WELCOME ****************************************

Enquiries: Ms. Winnie Wong or Prof. Wen J. Li, Department of Mechanical and Automation Engineering, CUHK at 2609 8337. *MAE Series (2009-10) is contained in the World-Wide Web home page at http://www3.mae.cuhk.edu.hk/maeseminars.php#mae.