Title :

Artificial Teeth: Dental Biofilm Analysis on a Chip

Speaker :

Mr. Raymond H. W. Lam

PhD Candidate, Department of Mechanical Engineering

Massachusetts Institute of Technology, USA

Venue :

Room 215, William M. W. Mong Engineering Building, CUHK

Date :

Jan 18, 2010, Monday
2:30 PM - 3:30 PM

Abstract :

Dental plaque is a complex biological coaggregation, with a composition highly micro-heterogeneous, variable and dependent in oral environment. Understanding the conditions promoting colonization and subsequent biofilm development is particularly important, as dental plaque formation is not only a precursor to tooth decay, but also induces more serious systemic health problems such as cardiovascular disease, pre-term labor, and diabetes especially when left untreated. While previous studies of dental biofilm have enhanced our understanding on their adhesion and organization properties, setting up a matrix of experimental conditions to mimic the microenvironments present in human mouth remains a laborious process. In this research, our aim is to develop a multiplexed microfluidic platform that will provide unprecedented control over the conditions required to stimulate the growth and development of complex dental biofilm. It functions as an effective and inexpensive analysis tool to dynamically adjust critical growth parameters such as bacteria stains, growth medium composition, medium flow rate and oxygenation levels. This platform can also be extended to general biofilm culture applications, contributing to the advancement of in vitro biofilm culture and demonstrating the realization of microfluidic technology for long-term complicated microbial co-culture.

Biography :

Mr. Raymond H. W. Lam is currently a PhD candidate in the Mechanical Engineering Department of Massachusetts Institute of Technology. He was educated at the Automation and Computer-Aided Engineering Department (currently called MAE) in the Chinese University of Hong Kong for 5 years (B.Eng 03` and M.Phil 05`). His interest in research was inspired by the education in MAE, and his master thesis under the supervision of Prof. Wen Li won the champion of IEEE Asia-Pacific Student Paper Contest 2006 (Graduate Section).

    **************************************** ALL ARE WELCOME ****************************************

Enquiries: Ms. Winnie Wong or Prof. Wen J. Li, Department of Mechanical and Automation Engineering, CUHK at 2609 8337. *MAE Series (2009-10) is contained in the World-Wide Web home page at http://www3.mae.cuhk.edu.hk/maeseminars.php#mae.